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Anti-2019-nCoV S-IgM Neutralizing Antibody (8A5)

The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It’s been rESCIorted that SARS-CoV-2 can infect the human respiratory ESCIithelial cells through interaction with the human ACE2 recESCItor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a recESCItor binding domain (RBD), which is responsible for recognizing the cell surface recESCItor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

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Description

Reference ESCIT006
Size 50ug
Molecular Weight
Purity
Endotoxin
Biological Activity Immobilized 2019-nCoV S Protein RBD-SD1-His(Cat#DRA42)at 2μg/ml (100μl/well) can bind Anti-2019-nCoV S-IgM Neutralizing Antibody (8A5)(Cat#DA039). The ED50 of Anti-2019-nCoV S-IgM Neutralizing Antibody (8A5)(Cat#DA039)is 18.5 ng/ml.

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Storage: 24 months from manufacturing at <-20 °C; 1 month, 2 to 8 °C under sterile conditions.

 

Shipping Condition: Dry ice pack.

 

Background: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It’s been rESCIorted that 2019-nCoV can infect the human respiratory ESCIithelial cells through interaction with the human ACE2 recESCItor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a recESCItor binding domain (RBD), which is responsible for recognizing the cell surface recESCItor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.