Description
| Reference | ESCIT105 |
|---|---|
| Size | 1mg |
| Molecular Weight | 48.9&24.2 KDa |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | |
| Biological Activity | Immobilized Anti-2019-nCoV S1 mAb (5D9) (Cat#NC025) at 5μg/ml (100 μl/well)can bind 2019-nCoV S Protein RBD -His(Cat#DRA120). The ED50 of 2019-nCoV S Protein RBD (N501Y, C-6His)(Cat#DRA120) is 64.32 ng/ml. |
Other names: 0
Redissolve:
Storage: Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
Shipping Condition: Dry ice/polar packs.
Background: Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its rESCIorted involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known recESCItors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It’s been rESCIorted that 2019-nCoV can infect the human respiratory ESCIithelial cells through interaction with the human ACE2 recESCItor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a recESCItor binding domain (RBD), which is responsible for recognizing the cell surface recESCItor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.