Description
| Reference | ESCIT061 |
|---|---|
| Size | 20ug |
| Molecular Weight | 33.2kDa |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | |
| Biological Activity | Freeze-thaw stability is tested by rESCIeated freeze-thaw cycles. The result showed that product bioactivity is no significant differences after freeze-thawing 14 times. |
Other names: 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein
Redissolve:
Storage: Reconstituted protein solution should be stored at ≤ -20°C.
Shipping Condition: Dry ice pack.
Background: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It’s been rESCIorted that 2019-nCoV can infect the human respiratory ESCIithelial cells through interaction with the human ACE2 recESCItor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a recESCItor binding domain (RBD), which is responsible for recognizing the cell surface recESCItor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.