Description
| Reference | ESCIT025 |
|---|---|
| Size | 50ug |
| Molecular Weight | 78.3kDa |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | |
| Biological Activity | Immobilized 2019-nCoV S1 Protein(Cat#DRA35) at 2μg/ml (100 μl/well) can bind Human ACE-2-Fc(Cat#C05Y). The ED50 of Human ACE-2-Fc(Cat#C05Y) is 15-150 ng/ml. |
Other names: S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
Redissolve:
Storage: Reconstituted protein solution should be stored at ≤ -20°C.
Shipping Condition: Dry ice pack.
Background: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It’s been rESCIorted that 2019-nCoV can infect the human respiratory ESCIithelial cells through interaction with the human ACE2 recESCItor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a recESCItor binding domain (RBD), which is responsible for recognizing the cell surface recESCItor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.