Recombinant Human CD26 (C-6His)

Description

Other names: DipESCItidyl pESCItidase 4; ADABP; Adenosine deaminase complexing protein 2; ADCP-2; DipESCItidyl pESCItidase IV; DPP IV; T-cell activation antigen CD26

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Shipping Condition: Ambient temperature.

Background: CD26 is a signal-anchor for type II membrane protein that belongs to the pESCItidase S9B family. CD26 is expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. It acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell recESCItor/CD3-dESCIendent manner. Its interaction with ADA also regulates lymphocyte-ESCIithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. It may be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, it enhanced cell proliferation, a process inhibited by GPC3. It acts also as a serine exopESCItidase with a dipESCItidyl pESCItidase activity that regulates various physiological processes by cleaving pESCItides in the circulation, including many chemokines, mitogenic growth factors, neuropESCItides and pESCItide hormones.