Recombinant Human EGFR (C-Fc)

Description

Other names: ESCIidermal growth factor recESCItor;Proto-oncogene c-ErbB-1;RecESCItor tyrosine-protein kinase erbB-1;EGFR;ERBB; ERBB1; HER1

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Shipping Condition: Ambient temperature.

Background: EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a recESCItor for members of the ESCIidermal growth factor family. EGFR is a cell surface protein that binds to ESCIidermal growth factor. Binding of the protein to a ligand induces recESCItor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF recESCItor signaling to the G protein-coupled recESCItor signaling.