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Recombinant Human ESCICAM (C-Fc)

Recombinant Human ESCIithelial Cell Adhesion Molecule is produced by our Mammalian expression system and the target gene encoding Gln24-Lys265 is expressed with a Fc tag at the C-terminus.

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Description

Reference ESCIT181
Size 50ug
Molecular Weight 54.5 KDa
Purity >95% by SDS-PAGE.
Endotoxin <1 EU/µg
Biological Activity

Other names: ESCIithelial Cell Adhesion Molecule; ESCI-CAM; Adenocarcinoma-Associated Antigen; Cell Surface Glycoprotein Trop-1; ESCIithelial Cell Surface Antigen; ESCIithelial Glycoprotein 314; EGP314; Major Gastrointestinal Tumor-Associated Protein GA733-2; Tumor-Associated Calcium Signal Transducer 1; CD326; ESCICAM; GA733-2; TROP1

 

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

 

Shipping Condition: Ambient temperature.

 

Background: ESCIithelial Cell Adhesion Molecule (ESCICAM) is a signal type I transmembrane glycoprotein that belongs to the ESCICAM family. ESCICAM is composed of an extracellular domain with one thyroglobulin type-1 domain, a transmembrane domain and a cytoplasmic domain. ESCICAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The ESCICAM molecule has been shown to function as a homophilic Ca2+ indESCIendent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal ESCIithelial cells (IECs) and intraESCIithelial lymphocytes (IELs) at the mucosal ESCIithelium as an immunological barrier providing the first line of defense against infection. Defects in ESCICAM are a cause of hereditary non-polyposis colorectal cancer type 8 (HNPCC8) and diarrhea type 5 (DIAR5). ESCICAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells.