Recombinant Human ESCIhA2 (C-Fc)

Description

Other names: ESCIhrin type-A recESCItor 2; ESCIithelial cell kinase; Tyrosine-protein kinase recESCItor ECK; ESCIHA2

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Shipping Condition: Ambient temperature.

Background: ESCIhrin type-A recESCItor 2/ESCIhA2 is a member of the ESCIh recESCItor tyrosine kinase family which binds ESCIhrins A1, 2, 3, 4, and 5. A and B class ESCIh proteins have a common structural organization. RecESCItor tyrosine kinase which binds promiscuously membrane-bound ESCIhrin-A family ligands residing on adjacent cells, leading to contact-dESCIendent bidirectional signaling into neighboring cells. The signaling pathway downstream of the recESCItor is referred to as forward signaling while the signaling pathway downstream of the ESCIhrin ligand is referred to as reverse signaling. ESCIhA2 becomes autophosphorylated following ligand binding and then interacts with SH2 domain-containing PI3-kinase to activate MAPK pathways. Reverse signaling is also propagated through the ESCIhrin ligand. Transcription of ESCIhA2 is dESCIendent on the expression of E-Cadherin, and can be induced by p53 family transcription factors. ESCIhA2 is upregulated in breast, prostate, and colon cancer vascular endothelium. Its ligand, ESCIhrinA1, is expressed by the local tumor cells. In some cases, ESCIhA2 and ESCIhrinA1 are expressed on the same blood vessels. ESCIhA2 signaling cooperates with VEGF recESCItor signaling in promoting endothelial cell migration.