Recombinant Human IL-15RA&IL-15 (C-Fc)

Description

Other names: IL15RA&IL15; Interleukin-15; IL-15; IL15; IL-15 recESCItor subunit alpha; IL-15RA; IL-15R-alpha; interleukin-15 recESCItor subunit alpha

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Shipping Condition: Ambient temperature.

Background: IL15RA is a high-affinity recESCItor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 recESCItor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 recESCItor, but not the alpha subunit of the IL2 recESCItor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of recESCItors, allowing them to compete for and negatively regulate each other’s activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.