Description
| Reference | ESCIT255 |
|---|---|
| Size | 50ug |
| Molecular Weight | 57.1 KDa |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <1 EU/µg |
| Biological Activity |
Other names: Interferon Regulatory Factor 5; IRF-5; IRF5
Redissolve:
Storage: Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
Shipping Condition: Dry ice/polar packs.
Background: Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad rESCIeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with suscESCItibility to systemic lupus erythematosus type 10. In addition, the genetic variations wil result in suscESCItibility to rheumatoid arthritis.