Description
| Reference | ESCIT036 |
|---|---|
| Size | 50ug |
| Molecular Weight | 13 KDa |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.01 EU/µg |
| Biological Activity | Immobilized Human TrkB-His (Cat#C507) at 2ug/ml (100 μl/well) can bind Human BDNF*(Cat#C076)*: Biotinylated by NHS-biotin prior to testing. The ED50 of Human BDNF*(Cat#C076) is 47.58 ng/ml. |
Other names: Brain-Derived Neurotrophic Factor; BDNF; Abrineurin
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Â
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping Condition: Ambient temperature.
Background: Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase recESCItor. It also binds with the LNGFR (for low-affinity nerve growth factor recESCItor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease.