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Recombinant Human NPR3 (C-Fc)

Recombinant Human Atrial Natriuretic PESCItide RecESCItor 3 is produced by our Mammalian expression system and the target gene encoding Thr24-Glu481 is expressed with a Fc tag at the C-terminus.

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Description

Reference ESCIT167
Size 50ug
Molecular Weight 77.5 KDa
Purity >95% by SDS-PAGE.
Endotoxin <1 EU/µg
Biological Activity

Other names: ANP-C; ANPR-C; NPR3; NPRC; NPR-C;ANPRC; C5orf23

 

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

 

Shipping Condition: Ambient temperature.

 

Background: Atrial Natriuretic PESCItide RecESCItor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic pESCItide recESCItors, is a type I transmembrane glycoprotein. The natriuretic system is key to the maintenance of vascular tone and cardiovascular homeostasis. RecESCItor for the natriuretic pESCItide hormones, binding with similar affinities atrial natriuretic pESCItide NPPA/ANP, brain natriuretic pESCItide NPPB/BNP, and C-type natriuretic pESCItide NPPC/CNP. May function as a clearance recESCItor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Osteocrin was found to be a specific ligand to NPR3. NPR3 is necessary for Osteocrin to regulate femoral, tibial, and metatarsal bone elongation.