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Recombinant Human PRKAR1A (C-6His)

Recombinant Human cAMP-dESCIendent Protein Kinase Regulatory Type I-alpha is produced by our Mammalian expression system and the target gene encoding Glu2-Val381 is expressed with a 6His tag at the C-terminus.

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Description

Reference ESCIT222
Size 50ug
Molecular Weight 44 KDa
Purity >95% by SDS-PAGE.
Endotoxin <1 EU/µg
Biological Activity

Other names: Tissue-specific extinguisher 1;TSE1

 

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

 

Shipping Condition: Ambient temperature.

 

Background: cAMP-dESCIendent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dESCIendent protein kinase A (PKA), which transduces the signal through phosphorylationof different target proteins. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hESCIatoma x fibroblast hybrids.