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Recombinant Human ST2 (C-6His)

Recombinant Human Interleukin-1 RecESCItor-like 1 is produced by our Mammalian expression system and the target gene encoding Lys19-Phe328 is expressed with a 6His tag at the C-terminus.

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Description

Reference ESCIT263
Size 10ug
Molecular Weight 36 KDa
Purity >95% by SDS-PAGE.
Endotoxin <1 EU/µg
Biological Activity Immobilized Human ST2-His(Cat#CI84) at 5μg/ml (100 μl/well) can bind Human IL-33-His(Cat#C233).The ED50 of Human IL-33-His(Cat#C233) is 8.44 ng/ml.

Other names: Interleukin-1 recESCItor-like 1;Protein ST2;DER4; ST2; T1

 

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

 

Shipping Condition: Ambient temperature.

 

Background: Interleukin 1 recESCItor-like 1(IL1RL1) is a member of the interleukin-1 recESCItor family, Contains 3 Ig-like C2-type domains and 1 TIR domain. It is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. IL1RL1 is a recESCItor for interleukin-33, its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 may possibly be involved in helper T-cell function. Soluble IL1RL1 also acts as a negative regulator of Th2 cytokine production, it directly implicated in the progression of cardiac disease.