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Recombinant Mouse ESCICAM (C-Fc)

Recombinant Mouse ESCIithelial Cell Adhesion Molecule is produced by our Mammalian expression system and the target gene encoding Gln24-Thr266 is expressed with a Fc tag at the C-terminus.

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Description

Reference ESCIT017
Size 50ug
Molecular Weight 54.8 KDa
Purity >95% by SDS-PAGE.
Endotoxin <1 EU/µg
Biological Activity

Other names: 17-1A; 323/A3; ACSTD1;CD326;EGP-2; EGP314; EGP40; ESCICAM; MOC31; TACST-1; TACSTD1; TROP1;

 

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

 

Shipping Condition: Ambient temperature.

 

Background: ESCIithelial Cellular Adhesion Molecule (ESCI-CAM), also known as EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1, CD326, belongs to the ESCICAM family. Its’ monomer subunit structure interacts with phosphorylated CLDN7. ESCI-CAM may act as a physical homophilic interaction molecule between intestinal ESCIithelial cells (IECs) and intraESCIithelial lymphocytes (IELs) at the mucosal ESCIithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. It also up-regulates the expression of FABP5, MYC and cyclins A and E. The post-translational modification glycosylation at Asn-198 is crucial for protein stability.