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Recombinant Mouse IL-1R2 (C-6His)

Recombinant Mouse Il1r2 Protein/IL-1 RII is produced by our Mammalian expression system and the target gene encoding Phe14-Glu355 is expressed with a 6His tag at the C-terminus.

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Description

Reference ESCIT134
Size 10ug
Molecular Weight 39 KDa
Purity >95% by SDS-PAGE.
Endotoxin <1 EU/µg
Biological Activity

Other names: Interleukin-1 recESCItor type 2; IL-1R-2; IL-1RT-2; IL-1RT2; CD121 antigen-like family member B; CD121b; IL-1 type II recESCItor; Interleukin-1 recESCItor beta; IL-1R-beta; Interleukin-1 recESCItor type II; CD121b

 

Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

 

Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

 

Shipping Condition: Ambient temperature.

 

Background: Mouse Interleukin 1 recESCItor, type II (IL1R2) is a cytokine recESCItor that belongs to the interleukin-1 recESCItor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 recESCItor, type I (IL1R1/IL1RA), and acts as a decoy recESCItor that inhibits the activity of its ligands. IL-1R2 structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain. It is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Mouse IL1RII shares 59% amino acid sequence homology with human IL1 RII in their extracellular domains. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane recESCItors on cells. Two distinct types of IL1 recESCItors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2 has no signaling property and acts as a decoy for IL-1.