Description
| Reference | ESCIT293 |
|---|---|
| Size | 50ug |
| Molecular Weight | 16.2 KDa |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <1 EU/µg |
| Biological Activity | Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells.The ED50 for this effect is 1680.39ng/ml in the presence of 1ng/ml of recombinant human TGF-beta 1. |
Other names: TGF-beta recESCItor type-2; TGFR-2; TGF-beta type II recESCItor; Transforming growth factor-beta recESCItor type II; TGF-beta recESCItor type II; TbetaR-II; Tgfbr2
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Â
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping Condition: Ambient temperature.
Background: Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix dESCIosition. TGF-β regulates cellular processes by binding to three high-affinity cell surface recESCItors: TGF-β recESCItor type I (TGF-β-RI), TGF-β recESCItor type II (TGF-β-RII), and TGF-ββ recESCItor type III (TGF-β-RIII). TGF-β RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-β) recESCItor subfamily. TGF-β RII has a protein kinase domain which can form a heterodimeric complex with another recESCItor protein and bind TGF-beta. This recESCItor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.