Description
| Reference | ESCIT274 |
|---|---|
| Size | 10ug |
| Molecular Weight | 21.2 KDa |
| Purity | >90% by SDS-PAGE. |
| Endotoxin | <1 EU/µg |
| Biological Activity |
Other names: Tumor necrosis factor recESCItor superfamily member 1A; Tumor necrosis factor recESCItor 1; Tumor necrosis factor recESCItor type I; Tnfr-1; Tnfr1; Tnfrsf1a;
Redissolve: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Â
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping Condition: Ambient temperature.
Background: Tumor necrosis factor recESCItor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor recESCItor superfamily. Tnfrsf1a is one of the major recESCItors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this recESCItor, and thus play regulatory roles in the signal transduction mediated by the recESCItor. Germline mutations of the extracellular domains of this recESCItor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome